Rhizoma coptidis exerts anti-inflammatory and anti-apoptotic effects through the above-mentioned ways, thereby has potential effects to diabetes, osteoarthritis, etc. Berberine reduces the levels of IL-1β, TNF-α in aortic sera and the mRNA expressions of NF-κBp65, iNOS, ICAM-1, IL-6 also reduced by inhibiting the migration of NF-κB to the nucleus in atherosclerotic mice [8, 18]. The gene discussed is NFKB1; the disease is osteoarthritis.