The results of current meta-analysis showed that ALA supplementation significantly decreased CRP (SMD = − 1.52; 95% CI, − 2.25, − 0.80; P < 0.001; I2: 93.7), IL-6 (SMD = − 1.96; 95% CI, − 2.60, − 1.32; P < 0.001; I2: 90.6), and TNF-α levels (SMD = − 2.62; 95% CI, − 3.70, − 1.55; P < 0.001; I2: 94.3) in patients with MetS and related disorders (Table 2 and Fig. 1). This evidence concerns the gene TNF and metabolic syndrome.