CD274 and neoplasm: Indoleamine 2,3-dioxygenase 1 (IDO1), cytotoxic T-lymphocyte-associated protein 4 (CTLA4), and programmed death-ligand 1 (PDL1) encode for proteins that are activated during tumor development in humans and play a role in suppressing immune responses, ultimately helping malignant cells escape T-cell mediated killing.