When the analysis was restricted to the biopsy-confirmed LN cohort, however, median and GM of serum IL-18 levels were confirmed to be statistically significantly increased in patients with active renal disease (Median [IQR]: 278 [213, 442] vs. 189 [124, 349] pg/ml; p = 0.03; ratio of GM 1.63; 95% CI 1.15, 2.31; p < 0.01). The gene discussed is IL18; the disease is lobular neoplasia.