Numbers of evidence indicated that PAQR3-deficient mice are resistant to high-fat-diet (HFD)-induced obesity and hepatic steatosis, accompanied by improvement of insulin resistance and insulin signaling, which suggests that PAQR3 plays a vital role in the regulation of glycolipid metabolism (25–28). This evidence concerns the gene PAQR3 and obesity due to melanocortin 4 receptor deficiency.