It is surprising that many (if not all) of the genes responsible for the onset of familial forms of PD, indeed, converge on mitochondria (Cieri et al., 2017) and besides the clear role played by PINK1 and Parkin as key regulators of mitochondrial integrity (Narendra et al., 2008), the list of PD-related genes linked to mitochondria is longer and α-syn is not an exception. The gene discussed is PRKN; the disease is Parkinson disease.