The expression of BDNF and TrkB were highly and negatively associated with histomorphometric and biomechanical remodeling parameters of colon, however we could not conclude that BDNF and TrkB are inhibiting factors or not for diabetes-induced colon remodeling, because novel contribution of BDNF and TrkB in diabetic intestinal dysfunction is scarce. The gene discussed is NTRK2; the disease is diabetes mellitus.