Consistently, autophagy markers, LC3BI and LC3BII expression was increased in UMUC3(HA-PHLPP2) accompanied with upregulated expression ATG7 and p62 and no observable alterations of ATG5/12 complex and Beclin1 (Fig. 6e), suggesting that ATG7 and p62 might be associated with PHLPP2-dependent upregulation of autophagy to promote MMP2 degradation in human BC cells. This evidence concerns the gene MMP2 and breast cancer.