Diabetic mice treated with either PXS-S2B or telmisartan had significant reduction in fibronectin mRNA (P < 0.01 vs. DM and P < 0.01 vs. DM respectively) and significant reduction in fibronectin immunostaining (P < 0.05 and P < 0.01 vs. DM respectively, Fig. 4). This evidence concerns the gene FN1 and diabetes mellitus.