Consistent with this early nuclear polarization of transcription factors in mitosis driving gene expression patterns that distinguish parent adenoma cells and daughter IC, the pole of the dividing cells with Zeb2+ compact chromatin already showed an E-cadherin+, CD44−, Pten+, pS473Akt− pattern of parent adenoma cells during cytokinesis, whereas the opposite pole with Zeb1+, Bmi1+, Yap1+ decondensed chromatin had transitioned to an E-cadherin−, CD44+, pS473Akt+ pattern of daughter IC (Fig. 5g). This evidence concerns the gene YAP1 and adenoma.