However, despite this induction of Zeb1 and EMT and continued repression of miR200, the invading cancer cells remained CD44lo (Fig. 7f), they did not show evidence of EF5++ clusters, a decondensed chromatin pattern resembling CGC, and we did not observe asymmetric distribution of Numb in any of the invading cells undergoing division (Fig. 7g). The gene discussed is NUMB; the disease is cancer.