However, previous study demonstrated that the rs1990760 T allele was associated with lower serum IFN-α levels in SLE patients who had anti-dsDNA antibodies (p = 0.0026)16, suggesting that the IFIH1 rs1990760 T allele was associated with increased IFN-induced gene expression in PBMCs and increased IFN sensitivity but lower serum IFN-α levels in anti-dsDNA–positive SLE patients16,41. This evidence concerns the gene IFNA1 and systemic lupus erythematosus.