When expression of these 20 genes was compared by t-test between TNBC and non-TNBC (i.e. ER+ HER2−, HER2+, TN), most genes were overexpressed in TNBC with statistical significance (p < 0.05) in either or both of the two breast cancer data sets (Supplementary Table S4). Here, ESR1 is linked to breast carcinoma.