Regarding the −418 G > C polymorphism in the TIMP-2 gene, the rarity of the C allele in our study population (frequency of 0.8% among HF patients and 0.2% among blood donors) is in accordance with the frequency observed in South-eastern Brazilians without Japanese descent and Europeans39, in whom the frequency of the C allele is 0.5% (https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=8179090). The gene discussed is TIMP2; the disease is hydrops fetalis.