TIMP1 and hydrops fetalis: Therefore, we tested the hypothesis that the 372 T > C polymorphism (Phe124Phe; rs4898) in the TIMP-1 gene and the −418 G > C polymorphism (rs8179090) in the TIMP-2 gene are associated with HF susceptibility, all-cause death, and/or HF-related death in Brazilians with reduced LV ejection fraction (LVEF).