In conclusion, the 372 T > C polymorphism (Phe124Phe; rs4898) in the TIMP-1 gene and the −418 G > C polymorphism (rs8179090) in the TIMP-2 gene are associated with neither HF susceptibility nor survival in HF patients with reduced LVEF in a population from South Brazil. Here, TIMP1 is linked to hydrops fetalis.