FANCC and metabolic disease: In our experiment, we found that ten metabolites inosine, hypoxanthine, pyrophosphate, L-asparagine, L-phenylalanine, acetyl-L-carnitine, beta-alanine, glutarylcarnitine, niacinamide and creatine were significantly upregulated in FANCC-high cells (Figure 5), supporting the understanding that there is a reversible link between cancer and the metabolic disorder.