In support of this, CDK1 activity has recently been shown to function downstream of the protein tyrosine phosphatase LAR to regulate adhesion complex formation in mouse embryonic fibroblasts stimulated with platelet-derived growth factor (Sarhan et al., 2016), and expression of CDK1 is required for αvβ3 integrin–dependent stimulation of prostate cancer cell migration (Manes et al., 2003). Here, CDK1 is linked to Familial prostate cancer.