CDK1 and prostate carcinoma: In support of this, CDK1 activity has recently been shown to function downstream of the protein tyrosine phosphatase LAR to regulate adhesion complex formation in mouse embryonic fibroblasts stimulated with platelet-derived growth factor (Sarhan et al., 2016), and expression of CDK1 is required for αvβ3 integrin–dependent stimulation of prostate cancer cell migration (Manes et al., 2003).