UNC13D and lung carcinoma: Whole-genome sequencing of human tumors (TCGA cBioPortal) revealed amplification of Munc13-4 mRNA (UNC13D) in breast, pancreatic, and lung carcinomas in up to 28% of tumors, whereas other members of the Munc13 family showed no consistent up-regulation (Gao et al., 2013).