UNC13D and cancer: Exosomes are extensively implicated in cancer progression (de Gassart et al., 2004; Liu et al., 2006; Clayton et al., 2007, 2008; Bobrie et al., 2011; Filipazzi et al., 2012; Kharaziha et al., 2012; Hoshino et al., 2013; Sung et al., 2015; Fu et al., 2016; Kalluri, 2016; Sinha et al., 2016), and we found that Munc13-4 KD strongly inhibited exosome secretion and prevented extracellular matrix degradation as a marker for early-stage metastasis.