CFTR regulates ovarian estrogen biosynthesis by amplifying the FSH-stimulated signal via the nuclear soluble adenylyl cyclase (sAC), defective CFTR-dependent regulation of estrogen production may underlie the ovarian disorders seen in CF and polycystic ovarian syndrome (PCOS) (Chen et al. 2012). The gene discussed is ADCY10; the disease is cystic fibrosis.