RyR2 mutations including those within the N-terminus have recently been linked to DCM (Haas et al., 2014), whereas mutations in cMyBP-C are very common in both HCM and DCM pathology (Carrier et al., 2015), with some cMyBP-C mutations reported to trigger arrhythmic events (Bahrudin et al., 2008; Berul et al., 2001). The gene discussed is RYR2; the disease is familial dilated cardiomyopathy.