Interestingly, high-resolution imaging of cMyBP-C and RyR2 revealed that sarcomere-bound cMyBP-C is the predominant form in healthy cardiomyocytes (Previs et al., 2015), with significant release of cMyBP-C into the cytosol after myocardial infarction/reperfusion (Govindan et al., 2012) and in pathologic hypertrophy (Sequeira et al., 2014). This evidence concerns the gene MYBPC3 and myocardial infarction.