TRPV1 and diabetes mellitus: TRPA1 and TRPV1 are important molecules in the sensitisation of peripheral nociceptive afferents (Cheng and Ji, 2008), and TRPV1 is directly sensitised by high-glucose conditions in sensory neurons (Lam et al., 2018) and during diabetes in vivo (Hong and Wiley, 2005; Khomula et al., 2013).