Furthermore, accumulating evidence demonstrates a vital role of the elongator complex in the CNS: variants in ELP2 are associated with neurodevelopmental disability (Cohen et al., 2015; Franić et al., 2015) and variants in ELP3 with amyotrophic lateral sclerosis (ALS) (Simpson et al., 2009). The gene discussed is ELP3; the disease is amyotrophic lateral sclerosis.