In comparison with saline-treated tMCAO mice, CORM-3-treated tMCAO mice had significantly fewer activated microglia in the peri-infarction zone on day 3 after ischemia (Fig. 2a–c), a finding that was confirmed by the concomitant reduction in Iba-1 protein expression (Fig. 2d, e). The gene discussed is AIF1; the disease is ischemia.