In contrast, chromophobe renal cell carcinoma (KICH) and kidney renal papillary cell carcinoma (KIRP), which so far have shown less evidence of susceptibility to anti-PD-1/PD-L1 blockade, have low-ranking median TIS scores and similar median mutation burdens than clear cell carcinomas. The gene discussed is CD274; the disease is clear cell adenocarcinoma.