Indeed, both CREB and PKA signalling have been implicated in Huntington disease [32, 33] and other neurodegenerative disorders [34], and CREB signalling is known to be required for long-term synaptic plasticity and axonal outgrowth [35], which was also found as one of the most significantly altered pathways. The gene discussed is CREB1; the disease is juvenile Huntington disease.