Our results confirmed that naringin can regulate the NLRP3-Caspase-1-IL-1β / IL-18 signaling pathway by the NLRP3 inflammasome, which can improve DKD by playing an anti-inflammatory role.This study provides new insights into the nephroprotective mechanism of naringin to improve DKD by anti-inflammatory responses. This evidence concerns the gene IL18 and diabetic kidney disease.