MMP8 and colorectal cancer: Colorectal cancer patients with low MMP-8 levels had a 5-year survival of 76.0% (95% CI 69.1–82.9) and those with high MMP-8 levels 62.7% (95% CI 54.7–70.7; HR (hazard ratio) 1.72, 95% CI 1.17–2.52, P = 0.005; Fig. 1).