MMP8 and malignant colon neoplasm: In subgroup analyses, survival was poor for patients with high MMP-8 and colon cancer (HR 2.00, 95% CI 1.10–3.64, P = 0.023, Additional file 3), with left-sided tumor (HR 1.80, 95% CI 1.17–2.77, P = 0.007), and with no systemic inflammatory response (HR 1.66, 95% CI 1.10–2.53, P = 0.017, Fig. 2a-b).