This is in contrast to a lower resolution CNV analysis of this patient that mapped the breakpoints to a region between HERC6 and HERC5 and an adjacent region outside of the CCSER1 gene.9 The impact of these novel findings is that there is now evidence that the Iowa and Lister kindreds both have a triplication breakpoint (right) that disrupts CCSER1, which may account for PD or non-PD phenotypic similarities in these patients/families. Here, HERC5 is linked to Parkinson disease.