TRAF3IP1 is a protein that interacts with TRAF3 and is has been observed to inhibit the innate type I IFN response.27 TRAF3IP1 was also higher expressed in cluster2 patients who had lower expression of IFNG and anti-tumor immune activity, suggesting a potential role for TRAF3IP1 regulation in inhibiting the anti-tumor immune response. The gene discussed is TRAF3; the disease is neoplasm.