CD8A and neoplasm: We additionally pursued an extensive analysis to de-convolute the heterogeneity of the tumor, showing that CD8+ T cell activity was likely enriched in cluser1 patient tumor samples and that chemosensitivity was seemingly linked to the immunocompetence of the ‘hot’ tumors.40 To this end, we observed CD8+ T cell tumor abundance to be associated with favorable patient prognosis.40–44 Of note, the pro-inflammatory IFNγ, which is a marker of CD8+ T cell mediated tumor regression and TIL abundance,45 was also significantly elevated in cluster1 samples.