CD8A and neoplasm: In order to suggest with further confidence at the level of immune cell type that CD8+ T-cells were more abundant in tumor samples from cluster1 patients, we applied a gene expression deconvolution framework to interpret the immunologically heterogeneous RNA-seq signals of each patient tumor sample.18 In line with our observations of elevated CD8A/B gene expression in cluster1, CD8+ T-cells mean abundance was significantly higher in cluster1 patient tumor samples than that of cluster2 (15.3% vs 7.4% of total immune cells, P = 1.00e-7; Fig. 4e and Table 1).