Coupling of uterine tumor hypertrophy and distal gonad atrophy could explain how RNAi of cdk-1 and wee-1.3 both inhibit tumor growth despite their opposing effects on the cell cycle: by suppressing distal gonad atrophy, wee-1.3 RNAi also suppresses uterine tumor growth. The gene discussed is CDK1; the disease is neoplasm.