The group identified survivin as one of the key players responsible for the innate chemoresistance of colorectal cancer stem cells and their aptamer-guided survivin RNAi enhanced sensitivity towards 5-FU or oxaliplatin in colorectal cancer stem cells, increased apoptosis, inhibited tumor growth and improved the overall survival of mice bearing xenograft colorectal cancer [138]. This evidence concerns the gene BIRC5 and neoplasm.