In a research, Madhavan et al. outlined that a combination of five proteins (CD44v6, Tspan8, EpCAM, MET and CD104) and four miRNAs (miR-1246, miR-4644, miR-3976 and miR-4306) in circulating tumor exosomes could recognize PC from healthy control, chronic pancreatitis, and benign pancreatic disease with a sensitivity and specificity of 100% and 80%, respectively [391]. Here, ITGB4 is linked to pachyonychia congenita.