We demonstrated that alteration of TNFAIP8 in prostate cancer cells dysregulates cell-cycle-related genes (e.g., cyclin-dependent kinases [CDKs], cyclins, proliferating cell nuclear antigen [PCNA]), and autophagy markers and effectors (e.g., microtubule-associated protein 1A/1B-light chain 3 beta [LC3β] I/II, Beclin1, eukaryotic translation initiation factor 4E-binding protein 1 [4E-BP1], p62, sirtuin 1 [SIRT1]). Here, PCNA is linked to Familial prostate cancer.