SLC2A1 and neoplasm: Therefore, the change between in vitro conditions where GLUT-1 and GLUT-2 expression are tightly regulated and the physiologically more complex in vivo environment where tumor cells need to adopt new metabolic strategies, would lead to a rearrangement of glucose transporters expressed at the cell surface in order to 1) efficiently uptake glucose and 2) maintain a high tumorigenic potential through sustained glycolysis.