Apoptosis of both HOS and U2OS cells was abrogated by lnc-RAB11B-AS1 down-regulation and was facilitated by lnc-RAB11B-AS1 up-regulation (Figure 2C and Supplementary Figure 2), suggesting that lnc-RAB11B-AS1 promote apoptosis of osteosarcoma cells. The gene discussed is RAB11B; the disease is osteosarcoma.