RAB11B and osteosarcoma: Next, luciferase reporter assay was conducted to explore the interaction between lnc-RAB11B-AS1 and the RAB11B. Reduction of lnc-RAB11B-AS1 caused increased luciferase activity of pGL3-Promoter-RAB11B in osteosarcoma cells, while up-regulation of the lncRNA resulted in contrary effect (Figure 8G and Supplementary Figure 5D).