Because Klotho, a tumor suppressor, has inhibitory effects on growth factor receptors such as the fibroblast growth factor receptor (FGFR), IGF-1R, and TGFβ1R [6–8], we hypothesized that Klotho would mitigate EGF-induced cell migration in cRCC. This evidence concerns the gene EGF and chromophobe renal cell carcinoma.