Among these genes were: MTSS1 (Metastasis suppressor) is regulated by DNMT3B [19] and has been associated with better outcome in normal karyotype AML [20]; PRG2, a proteoglycan with role in myeloid differentiation, PARP12, involved in death-receptor and MAPK signaling, members of tryptase family (TPSD1, TPSB2, TPSAB1). This evidence concerns the gene PRG2 and acute myeloid leukemia.