TOP2A and breast carcinoma: In the subgroup analysis of breast cancer subtypes, TOP2A overexpression was a significant prognostic factor in luminal B breast cancer (5-year RFS; TOP2A overexpression vs. no overexpression, 98.5% vs. 81.3%, p < 0.001, log-rank test); however, no such significant association was observed in other subtypes (Figure 1B–1E).