A Cancer Stem Cell Transcription Factor Activation Array (Signosis, Inc, number FA-1004) also found KLF4, MYC, NANOG, OCT-3/4, SOX-2 and SNAIL activated in both MCF-7 and T47D after treatment with the CM of HA-BrC cells (data not shown). The gene discussed is NANOG; the disease is cancer.