CTLA4 and cancer: Twenty-one patients had received immunotherapy treatments including: immune checkpoint inhibitors (12 patients, of which 8 received anti-CTLA4 mAb, one received anti-PD1 mAb and 3 received both), cancer vaccines (3 patients), IFN-alpha (3 patients), cancer vaccines and IFN-alpha (1 patient) and anti-LAG-3 mAb (2 patients).