Interestingly, high expression of 4 genes targeted by anti-tumor miRNAs was significantly associated with poor prognosis of patients with RCC according to TCGA database analyses (UHRF1: p = 4.87E-06, LOXL2: p = 0.0343, PLOD2: p = 0.000855 and SKA1: p = 1.44E-07). The gene discussed is LOXL2; the disease is renal cell carcinoma.