In this study, we conducted a case-control study to genotype the candidate SNPs in ATR-CHEK1 and ATM-CHEK2 pathway genes (rs35514263 in ATR; rs492510, rs558351 in CHKE1; rs189037 in ATM; rs2236141, rs5762748, rs2236142 and rs9620817 in CHEK2) and investigate the association with the risk of CRC in a Chinese population. Here, ATR is linked to colorectal carcinoma.