One locus from the region on Ots10 was within phosphatase and actin regulator 1 (PHACTR1), which is a key regulator of endothelial cells (Jarray et al., 2011) and is also significantly associated with coronary artery calcification in humans (van Setten et al., 2013). Here, PHACTR1 is linked to coronary artery calcification.