ERN1 and leukemia: Expression of XBP1s was observed in the initiation of NK cell-mediated direct cytotoxicity or antibody-dependent cell-mediated cytotoxicity (ADCC) in leukemia or lymphoma target cellsPharmacological inhibition of the IRE1α/XBP1s pathway significantly impaired both NK cell-mediated direct-cytotoxicity and antibody-dependent cell-mediated cytotoxicity (ADCC). This indicates that XBP1s is essential for optimal NK cell cytotoxicity