Corroboration to above studies, in mice with experimental arthritis, deletion of the IRE1α gene specifically in myeloid tissue- or inhibition of IRE1α with 8-formyl-7-hydroxy-4-methylcoumarin (4μ8c) compound decreased the production of pro-inflammatory cytokines, which further subsidized the joint inflammation (266). Here, ERN1 is linked to arthritic joint disease.