DDX41 and nephritis: Indeed, the transfer of ICs containing sialylated polyreactive IgG autoAbs from 56R+/−Fcgr2b−/− mice or sialylated antigen-specific monoclonal IgG Abs attenuated the development of the induced nephritis (Figure 4), whereas antigen-unspecific sialylated monoclonal IgG Abs failed to reach the inhibitory potential of antigen-specific sialylated IgG Abs.