Although the combined analysis of α-syn aggregates with other CSF biomarkers (e.g., Aβ42, t-Tau and p-Tau) can be used in the cases of uncertain diagnosis (e.g., patients affected by mixed AD/DLB pathology), in-depth investigations are still necessary to perform a differential diagnosis among different synucleinopathies. Here, MAPT is linked to Lewy body dementia.