Western blots were evaluated for differences in COL2A1, MMP-13, and MMP-3 in cartilage and IL-1β, MMP-13, MMP-3, and NF-κB p65 in the synovium among the groups of rats with T2DM-induced knee OA (Figure 5). This evidence concerns the gene COL2A1 and type 2 diabetes mellitus.