There is evidence that reelin can regulate adult hippocampal neurogenesis and dendritic spine plasticity (Pujadas et al., 2010), and our data show that rats subjected to repeated CORT injections have dampened reelin expression selectively in the proliferative subgranular zone of the dentate gyrus (Lussier et al., 2009) and also that antidepressant treatment normalizes depression-like behavior, hippocampal neurogenesis, and hippocampal reelin expression in tandem (Fenton et al., 2015). This evidence concerns the gene RELN and major depressive disorder.