Since M. tb infection induces COX-2 production [4] and COX-2 has been linked to regulation of Mcl-1 production in human lung adenocarcinoma cells [33], we first determined if COX-2 is important for PPARγ activity and the production of Mcl-1 during M. tb infection of human macrophages. Here, PPARG is linked to lung adenocarcinoma.