The sub-distribution hazard ratio (SHR) of sclerostin for cardiovascular mortality, adjusting for exposure time (dependent variable) and taking into account, in addition to sclerostin, the classical risk factors for mortality (age, presence and duration of diabetes, sex, prevalent CVD, pIMT, tobacco use, hypertension and eGFR), as independent variables, was 1.31 [95% CI 1.085–1.581] p = 0.005. The gene discussed is SOST; the disease is diabetes mellitus.