Relative to H596 NSCLC tumors implanted in wild-type SCID mice, H596 tumors implanted in homozygous human HGF knock-in (hHGFki/ki) mice exhibit enhanced growth rates and mesenchymal-like phenotypes, the latter assessed via immunofluorescence assays for E-cadherin and vimentin, markers of the epithelial and mesenchymal states, respectively [11]. Here, HGF is linked to non-small cell lung carcinoma.