Treatment with INCB053914 inhibited the phosphorylation of downstream PIM kinase substrates (p70S6K/S6 and 4E-BP1) in a dose-dependent manner in MOLM-16 (AML), Pfeiffer (DLBCL), and KMS-12-PE/BM (MM) cell lines (Fig 2B). Here, EIF4EBP1 is linked to acute myeloid leukemia.