Treatment with INCB053914 inhibited the phosphorylation of downstream PIM kinase substrates (p70S6K/S6 and 4E-BP1) in a dose-dependent manner in MOLM-16 (AML), Pfeiffer (DLBCL), and KMS-12-PE/BM (MM) cell lines (Fig 2B). The gene discussed is RPS6KB1; the disease is acute myeloid leukemia.