For example, expression of both PIM1 and PIM2 is elevated in diffuse large B-cell lymphoma (DLBCL), whereas PIM2 alone is more highly expressed in B-cell chronic lymphocytic leukemia, acute myeloid leukemia (AML), and multiple myeloma (MM) [1, 12, 14–17]. Here, PIM2 is linked to B-cell chronic lymphocytic leukemia.